Angiogenesis plays an essential role in tumor growth, invasion and metastasis. After initial pessimism about the usefulness of the antiangiogenic therapeutic approach for cancer, interest has increased in the development of antiangiogenic compounds after the first clinical approval of an antiangiogenic therapy. The anti‐vascular endothelial growth factor (VEGF) antibody bevacizumab has recently been approved for use in combination with chemotherapy for the treatment of metastatic colorectal and non‐small cell lung cancer patients. However, no survival benefit has been demonstrated in anti‐VEGF (...) monotherapy trials, probably due to the high complexity of tumor angiogenesis regulation. Experimental and clinical data, including the approval of the multitargeted drugs sunitinib and sorafenib, indicate that exciting results, including tumor regression, can be expected from the combined targeting of different pathways in the tumor angiogenesis scenario. Several obstacles, including the high cost of new molecular targeted drugs make this therapeutic approach difficult. BioEssays 29:1159–1168, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

We argue that the physics of complex materials and self-organizing processes should be made central to the biology of form. Rather than being encoded in genes, form emerges when cells and certain of their molecules mobilize physical forces, effects, and processes in a multicellular context. What is inherited from one generation to the next are not genetic programs for constructing organisms, but generative mechanisms of morphogenesis and pattern formation and the initial and boundary conditions for reproducing the specific traits of (...) a taxon. There is no inherent antagonism between this “physicalist” perspective and genetics, since physics acts on matter, and gene products are essential material components of living systems whose variability affects the systems’ parameters. We make this notion concrete by summarizing the concept of “dynamical patterning modules” (DPMs; Newman and Bhat, Phys Biol 5:1–14, 2008; Int J Dev Biol 53:693–705, 2009), an explicit physico-genetic framework for the origin and evolution of multicellular form in animals, as well as (when differences in interaction toolkit genes and applicable physical processes are taken into account) in multicellular plants (Hernández-Hernández et al., Int J Dev Biol 56:661–674, 2012). DPMs provide the missing link between development and evolution by revealing how genes acting in concert with physics can generate and transform morphology in a heritable fashion. (shrink)

Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC 4.1.1.22), an enzyme that still remains to be fully characterized. Nevertheless, during the last few years, important advances have been made in this field, including the generation and validation of the first three-dimensional model of the enzyme, which allows us to revisit previous results and conclusions. (...) This essay provides a comprehensive review of the current knowledge of the structural and functional characteristics of mammalian histidine decarboxylase. BioEssays 27:57–63, 2005. © 2004 Wiley Periodicals, Inc. (shrink)

La experiencia de la Grecia antigua creó el concepto de política y sistematizó alrededor de él una concepción profunda de su significado. Los tres pensadores clásicos de la filosofía política (Sócrates aunque no produjo escritos propios; Platón quien solamente enfatizó la política ideal, y Aristótel..

Background Changes in health needs led to an increase in virtual care practices such as telemedicine. Nursing plays an essential role in this practice as it is the key to accessing the healthcare system. It is important that this branch of nursing is developed considering all the ethical aspects of nursing care, and not just the legal concepts of the practice. However, this question has not been widely explored in the literature and it is of crucial relevance in the new (...) concept of care. Objective The purpose of this scoping review is to identify the ethical aspects of the development of telemedicine from a nursing practice perspective. Methods A scoping review of the literature based on Arksey and O’Malley’s framework. The search was conducted in Scopus, PubMed/MEDLINE and CINAHL databases, from 2012 to 2022. A total of 1322 articles were retrieved, of which 12 met the inclusion criteria. Ethical considerations The research was conducted in accordance with the best scientific practices. Findings The most relevant aspects were the safety of the patient, the benefits for the user and the digital competence of the professionals. Informed consent and patient’s willingness to use new technologies were relevant to the practice, as was person-centered care and how telemedicine can influence the quality of the therapeutic relationship. Another relevant issue was the concern about professional competence for optimal outcomes. Conclusion It is necessary to further explore and develop the ethical aspects of the new practices, disassociating them from the legal aspects only. Professionals demand more training providing them with more competence and confidence. (shrink)

In _Althusser, The Infinite Farewell_—originally published in Spanish and appearing here in English for the first time—Emilio de Ípola contends that Althusser’s oeuvre is divided between two fundamentally different and at times contradictory projects. The first is the familiar Althusser, that of _For Marx_ and _Reading Capital_. Symptomatically reading these canonical texts alongside Althusser’s lesser-known writings, de Ípola reveals a second, subterranean current of thought that flows throughout Althusser’s classic formulations and which only gains explicit expression in his later (...) works. This subterranean current leads Althusser to move toward an aleatory materialism, or a materialism of the encounter. By explicating this key aspect of Althusser’s theoretical practice, de Ípola revitalizes classic debates concerning major theoretico-political topics, including the relationship between Marxism, structuralism, and psychoanalysis; the difference between ideology, philosophy, and science; and the role of contingency and subjectivity in political encounters and social transformation. In so doing, he underscores Althusser’s continuing importance to political theory and Marxist and post-Marxist thought. (shrink)

En este trabajo, después de contrastar la opinión de Kant y Aristóteles sobre la responsabilidad y la libertad ante la coacción, y tras unas sucintas consideraciones sobre el tema de la libertad en el pensamiento islámico, se pasa revista a lo que sobre la coacción han dicho los pensadores más representativos del área islámica clásica. Estos pensadores son, ante todo, los mutakallimíes, los “teólogos” del islam, distinguiéndose entre ellos un grupo, los muʿtazilíes, que son los que han dado mayor entrada (...) a la razón en sus especulaciones, y entre estos destacan los análisis de ‘Abd al-Jabbâr que es el autor que más se ha ocupado de este asunto. Finalmente se contrasta la opinión de este autor con las de al-Bâqillânî y Algazel, cuya solución es muy próxima a la de Kant. Sigue un breve Apéndice para ilustrar la cuestión tratada a través de las reflexiones de Semprun y Améry sobre su experiencia de la coacción sufrida. (shrink)

Este trabajo examina los diferentes reparos que el recurso a las ideas procedentes de la cultura pública como base de su concepción de la justicia le ha procurado a Rawls. Ese examen se propone establecer dos conclusiones. Primera, frente a quienes sugieren que, con la apelación a tales fundamentos, la solidez del método de justificación que Rawls articula se resiente gravemente y los que esgrimen que, con esa apelación, Rawls renuncia a las pretensiones de universalidad que son consustanciales a la (...) doctrina liberal, intenta poner de manifiesto que el papel que esas ideas cumplen en la justificación de una concepción política de la justicia como la suya únicamente muestra la congruencia que la obra de Rawls exhibe en la manera de entender la naturaleza de la justificación y la clase de elementos sobre los cuales se articula. Segunda, frente a quienes sostienen que el método de justificación empleado por Rawls entraña alguna forma de relativismo o etnocentrismo, trata de evidenciar que ese método no conduce a ese tipo de posiciones, por más que tome como base nuestros juicios considerados y nociones políticas fundamentales. (shrink)

RESUMENSe realzia un estudio sobre el ámbito de problemas que conciernen a la Estética de la comunicación en cuanto parte del os estudios estéticos dedicada a la investigación de la dimensión estética de lso actos comunicativos y de las relaciones que con ello se establecen entre la Estética y la Teoría de la comunicación por un lado y los fenómenos estéticos y los medios de comunicaciónPALABRAS CLAVEESTETICA-COMUNICACIÒN-ARTE-MEDIOS DE COMUNICACIONABSTRACTThis is a study on the problems of the Aesthetics of Communication, being (...) a part of tgeneral Aesthetics focused on the aesthetic dimension of communication and the relations, on one side, betweeen Aesthetics and the Theory of communnication, and, on the other, betwerrn the aesthetic issues and the mediaKEYWORDSAESTHETICS-COMUNICATION -ART-MEDIA. (shrink)

This article examines the Kantian ideas on motion in his work Metaphysical Foundations of Natural Science. In that essay, Kant holds that motion as a concept—from its connotation as elemental and fundamental predicament of the material reality—mobilises in matter all the characteristics of its essence as a property. Nevertheless conceiving motion as a concept does not enable us to confirm the existence of motion itself in the natural world because ‘the possibility of specific natural things can’t be discovered from their (...) mere concepts.’. Therefore, the concept of movement does not evidence the existence of the movement or its characteristics and properties. Such claim would imply that motion as a concept is not evidence of the existence of motion as such and, therefore, the properties of matter cannot be mobilised based on that concept because they are characteristics of the essence of motion. Then, how does Kant intend to denote motion? Why pretend to explain matter form the concept of motion if a pure concept is, by definition, independent of the data obtained from the sensibility?. Therefore, we will demonstrate that such weakness is the breaking point of the Kantian concept of motion in his “dynamic-metaphysical” model. (shrink)

The aim of this work is to question the neoliberal governance standing from Michel Foucault’s philosophy. The starting point is that Foucaultian reflection is able to trigger a characterization of neoliberal rationality which can show the connection between freedom, individual and government. Likewise, the hypothesis of this writing holds that Foucault’s notion of ontology of actuality allows to criticize in a quite radical way the identities that the neoliberal logic imposes. From this point of view, it will be possible to (...) see the precise sense of ethical and political actions which, not disregarding the individual autonomy and the communal bond, are able to resist the regime of power, knowledge and subjectivity that neoliberalism attempts to impose. (shrink)

Filosofía del lenguaje como historia de la filosofía.--El lenguaje filosófico griego: hacía una revisión de la terminología.--Lenguaje e historia de la filosofía.--Lenguaje e interpretación filosófica.--"Lógico" y "terminológico" en filosofía (una nota introductoría al enguaje de Heidegger).--Un modelo de semántica filosófica.--Semántica cartesiana (una lectura del Discours de la méthode).

Used for purposes related to tourism, advertising or politics, postcards allow the showcasing of different forms in which the urhan is represented. Identifyng exported visions of Montevideo through postcards published during the end of the 19" centuy and first decades of the 20", this paper shows how their publishers gave priority to the representation of news areas of the city instead of the more traditional. The intention with this was to portray the idea of progress and social welfare that immigrants, (...) one of the main buyers of postcards at this time, wanted to transrmit to their relatives in their respective countries of origin. (shrink)

Presentación del Monográfico sobre Racionalidad y Neurociencias (Daímon 59, 2013).

El objetivo del presente estudio fue analizar las propiedades psicométricas de la ENCAO en trabajadores de una empresa privada del sector de hidrocarburos en Lima Metropolitana. Para esto, se evaluó a una muestra de 384 participantes, 64 % mujeres y 36 % hombres, con edades entre los 19 y los 56 años. Como evidencias de validez de la estructura interna del instrumento, se realizó un análisis factorial exploratorio y un análisis factorial confirmatorio, donde se encontró una estructra de cuatro factores (...) relacionados con los 21 ítems de la escala, los cuales explicaron el 60.33 % de la varianza total y obtuvieron adecuados índices de bondad de ajuste. Como fuente de validez externa se obtuvieron correlaciones moderadas con la variable satisfacción laboral. Los coeficientes alfa de Cronbach de los cuatro factores oscilaron entre.60 y.84. Se concluye que la ENCAO y sus puntuaciones derivadas son una medida válida y fiable para medir el aprendizaje organizacional en el sector laboral evaluado.Palabras clave: aprendizaje organizacional; validez; confiabilidad; análisis factorial. Psychometric properties of the Organizational-Learning Levels and Conditions Scale in employees of a Peruvian private companyThe objective of the present study was to analyze the psychometric properties of the ENCAO in employees of a private company of the hydrocarbon sector in Metropolitan Lima. A sample of 384 participants was evaluated, of whom 64 % were women and 36% men, aged between 19 and 56 years. As evidences of validity related to the internal structure, an exploratory factorial analysis and a confirmatory factorial analysis were carried out, resulting in a structure of four related factors with the 21 items on the scale that explained 60.33 % of the total variance and with adequate goodness of fit indexes. As a source of external validity, moderate correlations were obtained with the variable Job Satisfaction. The Cronbach alpha coefficients of the four factors obtained ranged between.60 and.84. It is concluded that the ENCAO and its derived scores are a valid and reliable measure to measure organizational learning in the evaluated labor sector.Key words: organizational learning; validity; reliability; factorial analysis. Propriedades psicométricas da Escala de Níveis e Condições de Aprendizagem Organizacional em trabalhadores de uma empresa privada peruanaResumoO objetivo do presente estudo foi analisar as propriedades psicométricas da ENCAO em trabalhadores de uma empresa privada do setor de hidrocarbonetos na região metropolitana de Lima, no Peru. Para isso, avaliou-se uma amostra de 384 participantes, 64 % mulheres e 36 % homens, com idades compreendidas entre 19 e 56 anos. Como evidências de validade relacionada à estrutura interna, realizou-se uma análise fatorial exploratória e uma análise fatorial confirmatória com as quais foi encontrada uma estrutura de quatro fatores relacionados com os 21 itens da escala, os quais explicaram o 60.33 % da variância total e obtiveram adequados índices de bondade de ajuste. Como fonte de validade externa foram obtidas correlações moderadas com a variável satisfação laboral. Os coeficientes alfa de Cronbach dos quatro fatores oscilaram entre.60 e.84. Conclui-se que a ENCAO e suas pontuações derivadas são uma medida válida e fiável para medir a aprendizagem organizacional no setor laboral avaliado.Palavras-chave: aprendizagem organizacional; validade; confiabilidade; análise fatorial. (shrink)

Quantum optics does not give a local explanation of the coincidence counts in spatially separated photodetectors. This is the case for a wide variety of phenomena, including the anticorrelated counting rates in the two channels of a beam splitter, the coincident counting rates of the two “photons” in an atomic cascade, and the “antibunching” observed in resonance fluorescence.We propose a local realist theory that explains all of these data in a consistent manner. The theory uses a completely classical description of (...) the electromagnetic field, but with boundary conditions of the far field that are equivalent to assuming a real fluctuating, zero-point field. It is related to stochastic electrodynamics similarly to the way classical optics is related to classical electromagnetic theory.The quantitative aspects of the theory are developed sufficiently to show that there is agreement with all experiments performed till now. (shrink)

Providing the first English translation of Análisis del ser del mexicano, this book features a full biography of Uranga, a detailed overview of the translated text, and discussion of Uranga's relevance to contemporary debates in the phenomenology of culture, the philosophy of liberation, Latin American philosophy and phenomenology itself. Reading Uranga's brilliant words expertly translated and introduced by Carlos Alberto Sánchez finally allows us to understand why this Mexican philosopher is considered one of the most fearless and original thinkers of (...) the 20th century. (shrink)

Resumen:En el marco de su filosofía de la moneda Locke desarrolla un concepto de ésta como algo que pertenece a la naturaleza de las cosas, pero cuyo valor debe promulgarse políticamente una sola vez y para siempre. A su juicio la moneda es el oro o la plata, y su ordenamiento está dictado por el orden de la razón natural, lo que obliga a los hombres a erigir su institución respetando esta norma natural de las cosas con la actitud de (...) una promesa inquebrantable. Más allá de la fijación que ordena el valor de la moneda a la naturaleza intrínseca del buen orden social, la intervención estatal en la creación y gestión de la moneda es juzgada en cambio como esencialmente perniciosa. El presente artículo estudia la función que cumple este peculiar concepto de la moneda en cuanto antecedente temprano del mito liberal de la economía como una supuesta disciplina científica cuyo objeto epistémico sería el mercado, entendido éste análogamente, bajo el influjo de las ideas deístas del siglo XVIII, como un producto del orden espontáneo y virtuoso de la sociedad.Palabras clave: Locke; moneda; liberalismo; marginalismo; patrón oro. (shrink)

Este trabajo surge de la tesis de Maestría en Educación Superior denominada "El campo de la Tecnología Educativa en los planes de estudio de la carrera de Ciencias de la Educación de la Facultad de Filosofía y Letras, Universidad Nacional de Cuyo". Allí se analizan los sentidos plasmados en los planes de estudio y en las prácticas de los docentes que formaron parte del campo. Aquí, trabajamos específicamente los hallazgos en los planes de estudio, desde una perspectiva hermenéutico-interpretativa, realizando un (...) estudio longitudinal, desde la creación de la carrera, en 1986, hasta el año 2009. En este artículo ponemos especial hincapié en cómo se refleja en los planes de estudio y en el campo de la Tecnología Educativa, la influencia de los macro y micro contextos de cada época histórica, marcando rupturas y continuidades en el significado que se le atribuyó a dicho campo dentro de la carrera de Ciencias de la Educación. También y como consecuencia de ello, los aspectos positivos, así como los espacios vacíos para la formación del docente y del licenciado. (shrink)

Se trata de analizar el puesto que ocupa El tema de nuestro tiempo en el conjunto de la obra de Ortega, en su camino hacia la llamada “Segunda navegación”, es decir, hacia su filosofía de madurez. Después de contextualizar el libro en la cultura europea de la época, describiendo las novedades que acontecieron en torno a 1921-23 y la situación histórica por la que atravesaba España, en plena crisis del sistema de la Restauración, se entra en el examen de los (...) conceptos nucleares “vida”, “generación”, “racionalismo”, “perspectivismo”, en torno a los cuales Ortega elabora su propuesta filosófica. Las grandes cuestiones de la cultura europea –políticas, morales, el sentido de la Historia– deben ser examinadas a la nueva luz de la razón vital, agotadas las fórmulas de la razón pura. Finalmente, se procede a una evaluación crítica del Tema. Ortega no logra renovar la idea nuclear de “vida humana” por depender aún de un enfoque naturalista y fiar la fundamentación de la razón vital a una ciencia nueva y no a una filosofía primera, como propondrá desde los cursos y textos de los años 30. (shrink)

La noción de emergencia acompaña a la Filosofía de la Biología desde finales del siglo XIX, afirmando que las propiedades de los sistemas biológicos no pueden deducirse de las de sus componentes. A lo largo del siglo XX las caracterizaciones de este concepto se han apoyado en cuatro pilares, impredecibilidad, novedad, restricción y causación descendente, pilares ligados a la asunción de una jerarquización de la realidad en niveles de organización. En este trabajo intento demostrar que puede explicarse la naturaleza de (...) las propiedades biológicas sin hacer referencia a la emergencia utilizando como herramienta la noción de cuasi-descomponibilidad propuesta originariamente por Herbert Simon. (shrink)